Waa maxay Abuurka Jujuube?
Abuurka abuur Jujube waa qayb firfircoon oo ka kooban geedo-dhaqameed Shiinees ah oo Ziziphus jujuba var ah. spinosa iyada oo loo marayo tignoolajiyada soo saarista casriga ah. Isticmaalka habka soo saarista heerkulka hooseeya -, waxay si buuxda u ilaalisaa cyclopeptides iyo flavonoid glycosides. Loo yaqaan "Oriental Sleep Berry", soosaarkan dabiiciga ah wuxuu noqday xal cilmiyeed hagaajinta tayada hurdada.
Qaybaha Muhiimka ah ee Bioactive & Mechanisms
Jujubosides
Si gaar ah u hawlgeliyay GABA{0}}Qaybiyayaasha (40-60% korodhka xidhiidhka)
Wuxuu nidaamiyaa shaqada dhidibka hypothalamic{0}}pituitary-adrenal (HPA)
Waxay joojisaa dareemayaasha glutamatergic oo aad u kacsan
Flavonoids Glycosides
Waxay kaxaysaa hurdada{0}} khalkhal ku dhaca xagjirnimada xorta ah
Waxay kordhisaa maskaxda 5-HT heerarka (25-30% sare u kaca)
Waxay ka ilaalisaa neerfayaasha hippocampal waxyeelada oksaydhka
Cyclopeptides
Sadex geesood oo gaar ah-qaabdhismeedka meertada cabbirkiisu wuxuu wanaajiyaa dhexgalka BBB
Waxay kordhisaa -mudada hurdo mawjada oo gaabis ah (35-45 daqiiqo ayaa kordha)
Waxay beddeshaa hiddo-wadaha saacada wareega (Saacadda, Bmal1) muujinta
Faa'iidooyinka caafimaad ahaan la xaqiijiyay
Horumarinta tayada hurdada
50-60% hoos u dhaca bilawga hurdada
Waxtarka hurdada ayaa kor u kacay in ka badan 85%
70-80% hoos u dhaca baraaruga habeenkii
Saamaynta Anxiolytic
Waxay yaraysaa heerarka cortisol salivary (30-35% hoos u dhaca)
Waxay wanaajisaa kala duwanaanshaha garaaca wadnaha (HRV) tusmooyinka
Waxay yaraynaysaa xanuunka guud ee walaaca (GAD).
Hawlaha Neuroprotective
Wuxuu joojiyaa - isku darka amyloid (40-50% dhimis)
Waxay kordhisaa balaastikada synaptik
Waxay hagaajisaa garaadka khafiifka ah (MCI)
Tilmaamaha Isticmaalka
Qiyaasta: 200-400mg/maalintii (10% jujubosides)
Sida ugu fiican ee la qaato: 30 daqiiqo ka hor wakhtiga jiifka oo lagu cabbo biyo diiran
Koorsada: Natiijooyin muhiim ah 2-4 toddobaad ka dib
Ka taxadaritaan
v Iska ilaali isticmaalka isku mar ah ee daawada dejiyaha
v Digniin ku socota bukaanada hypotensive
v La socodka joogtada ah ee shaqada beerka ee isticmaalka muddada dheer -
Tilmaamayaasha Tayada
① Ka weyn ama la mid ah 10% jujuboside content (HPLC waa la xaqiijiyay)
② Full- tignoolajiyada soo saarista spectrum
③ Haraaga bir culus/dabacyada sunta cayayaanka-Shahadaad bilaasha ah
Marqaatiyada Isticmaalaha
"Laba toddobaad ka dib, sannadahaygii - hurdo dheer oo bilawday dhib ayaa si weyn u soo hagaagtay" - 42 madaxa fulinta
"80% hoos u dhac ku yimid baraaruga habeenkii oo ay sababto iftiinka kulul ee menopausal" - 50 yo isticmaale dumar ah
