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Sharaxaada Alaabta

L{{0}Borneol, oo sidoo kale loo yaqaan Ai Pian ee Shiinaha, waa isku dhaf si dabiici ah u soo baxa crystalline laga soo saaray caleemaha cusub ee Blumea balsamifera (Asteraceae). Qaybta firfircoonida aasaasiga ah waaL-Borneol, taas oo ah mid ka mid ah saddexda ilood ee ugu waaweyn ee "Borneol" (labada kale waa borneol synthetic iyo dabiiciga D-Borneol). Waa isomer-ka levorotatory ee D-Borneol, oo leh sifooyin jidheed oo kala duwan, waxqabadyo dawooyinka, iyo codsiyada. Hoos waxaa ku yaal dulmar faahfaahsan:

Isha iyo Diyaarinta

Isha dhirta:
Blumea balsamifera waa geedo ama geed hoosaadyo wali jira oo inta badan lagu qaybiyo gobolada Yunnan, Guizhou, iyo Guangxi ee Shiinaha. Caleemaha cusub ayaa ah alaabta kaliya ee ceyriinka ah ee lagu soo saaro dabiiciga L-Borneol.

Habka Soo saarista:
L{{0}Borneol waxa lagu helaa uumiga saliidda lagama maarmaanka ah ee laga helo caleemaha Blumea balsamifera, oo ay ku xigto qaboojinta crystallization iyo recrystallization si loo sifeeyo. Alaabta ka soo baxday waxay u muuqataa sida badh{2} hufan, kiristaalo cad oo xoog leh, caraf qaboojin leh. Marka la gubo, waxa ay sii daysay qiiq cufan iyo olol dhalaalaya.

Heerarka Tayada:
Marka loo eego Pharmacopoeia Shiinaha, L-Waxyaabaha ku jira Borneol waa inaysan ka yarayn85.0%, halka isoborneol waa inuusan dhaafin5.0%iyo Camphor waa inuusan dhaafin10.0%.

Halabuurka iyo Qaab-dhismeedka

Qaybta koowaad:
L{{0}Borneol (C₁₀H₁₈O, miisaanka kelli: 154.25) waa aalkolo monoterpenoid levorotatory ah. Qaab dhismeedka kiimikada waa sawirka muraayada D-Borneol.

Meesha dhalaalaysa:201-205 darajo

Wareeg gaar ah:[ ] ᴅ²⁰=-37.74 darajo (ee ethanol)

Qaybaha Yaryar:
Waxa ku jira cadadka eucalyptol, L{0}camphor, iyo sesquiterpene aalkolada, kuwaas oo si wada jir ah gacan uga geysta udgoonka sifada iyo hawlaha bayoolojiga ee dheeriga ah.

Isbarbardhigga Noocyada Kale ee Borneol

Muuqaal	L-Borneol (Ai Pian)	D-Borneol (Borneolum dabiiciga ah ee ka socda Cinnamomum camphora)	Borneol synthetic (Rasemic Borneol)
Xigasho	Laga soosaaray caleemaha Blumea balsamifera (Asteraceae)	Laga soo saaray resins ama laamaha Cinnamomum camphora	Kiimiko ahaan laga sameeyay turpentine ama kafur
Waxqabadka indhaha	Levorotatory ([ ]ᴅ²⁰=-37.7 darajo)	Dextrorotatory ([ ]ᴅ²⁰=+37.7 darajo)	Racemic (muuqaal aan firfircoonayn)
Qaybta ugu muhiimsan	L -Borneol (Ka weyn ama la mid ah 85%)	D -Borneol (Ka weyn ama la mid ah 99%)	Racemic Borneol oo leh isoborneol iyo wasakh
Meesha dhalaalaysa	201-205 darajo	208 darajo	210.5 darajo
ur	Udgoon adag oo soo kicinaya	Udgoon iyo caraf udgoon	fiiqan, kiimiko ah{0}} sida ur leh qoraalo haraaga ah
Badbaadada	Si dabiici ah u soo jeeda, suntan hoose	Dabiici ah, badbaado sare leh	Waxa ku jiri kara sunta wasakhda ah sida Isoborneol
Diiradda Farmaajo	Dhaqdhaqaaqa adag ee ka-hortagga bararka iyo xanuunka	Saamaynta soo kicinta iyo baraarujinta caanka ah	Waxtarka daciifka ah, xanaaq badan

Tallaabooyinka Farmasiga iyo Codsiyada Caafimaadka

Kicinta habka dhexe ee neerfaha (Ficilka soo noolaynta):L{{0}Borneol waxay si degdeg ah uga gudubtaa xannibaadaha maskaxda iyo dhiigga waxayna kordhisaa shaqada habdhiska dhexe ee neerfayaasha. Waxa loo isticmaalaa in lagu daweeyo xaaladaha ay ka mid yihiin istaroogga - koomo-ka-soo-baxa, xummad-xumada, iyo cudurrada kale ee "xiran." Nidaamkeedu wuxuu la xiriiraa qaabeynta soo-dhoweynta GABA iyo ka-hortagga apoptosis neuronal.

Ka-hortagga-Saamaynta bararka iyo xanuunka:Daraasaduhu waxay muujinayaan in L -Borneol ay si weyn u yarayso carrageenan{1}bararka jiirka ee keena bararka jiirka iyo acetic acid-ku-ku-qoritaannada jiirarka, taasoo muujinaysa saamaynta ka-hortagga bararka ee sarreeya marka la barbar dhigo borneol synthetic. Kiliinik ahaan, waxaa loo isticmaalaa boogaha afka, pharyngitis, iyo arthritis.

Kobciyaha nuugista Transdermal:Sida kobcinta galinta dabiiciga ah, L-Borneol waxa ay wanaajisaa dabar goynta stratum corneum waxayna kordhisaa waxtarka daawooyinka jirka la marsiiyo (cadar, balastar, iwm.). Qaababka isku dhafan ee ka kooban L-Borneol waxay wanaajisaa saamaynta suuxinta gudaha iyo qoto-dheeraanta gudbinta daroogada.

Waxqabadka Ka-hortagga jeermiska iyo Ka-hortagga jeermiska:Waxay muujisaa saamaynta ka-hortagga Staphylococcus aureus, Escherichia coli, iyo Candida albicans, taasoo ka dhigaysa mid waxtar u leh daawaynta caabuqyada maqaarka, warbaahinta otitis, iyo xaaladaha la midka ah.

Codsiyada kale

Ophthalmology:Loo isticmaalo dhibcooyinka indhaha (tusaale, Ba Bao Eye Drops) si loo yareeyo casaanka, bararka, iyo mugdiga corneal.

Maqaarka:Codsaday galleyda, gubashada, cambaarta, iyo bogsashada nabarrada.

Daryeelka Shakhsi ahaaneed iyo Warshadaha udgoonka:U adeega sida walxo udgoon qaali ah oo ku jira isqurxinta iyo cadarka, oo bixisa - ur dheer oo waara, oo nasasho leh.

Aqoonsiga iyo Qiimaynta Tayada

Astaamaha Alaabta Saxda ah:

Muuqashada:Semi{0} hufan, jajabyo crystalline cad; adag oo jajaban, oo aan si fudud loo jajabin.

Udgoon:Nasteexo leh oo dabiici ah oo aan lahayn wax ur xun.

Tijaabada Gubashada:Waxay soo saartaa qiiq cufan oo leh olol dhalaalaya oo aan lahayn hadhaaga madow.

Sinada Caadiga ah:

Borneol synthetic:Kiristaalo aan midab lahayn oo hufan, jilicsan oo jajaban, waxay ku gubaan olol huruud ah iyo turpentine{0}} sida ur u eg.

Alaabooyinka isku dhafan:Waxa ku jiri kara camphor ama menthol{0}} falanqaynta qaybaha (tusaale, GC-MS) ayaa looga baahan yahay aqoonsiga saxda ah.

L{{0}Borneol (Ai Pian), sida daawada dhaqameed ee Shiineeska ah iyo iskudhis caraf udgoon, waxay leedahay hawlo indho-indhayn oo gaar ah iyo hawlo dawooyin ah. Asalkeeda dabiiciga ah, badbaadada, iyo kala duwanaanshiyaha daaweynta ayaa ka dhigaya mid aan lagu beddeli karin codsiyada caafimaadka iyo qurxinta labadaba. Daraasadaha dawooyinka casriga ah ayaa ansixiyay waxtarkeeda iyo badbaadada, iyo hal-abuurnimada mustaqbalka ayaa la filayaa inay sii ballaariso doorkeeda qaababka horumarsan iyo daawada saxda ah.